Molecular Analysis of Nipple Fluid for Breast Cancer Screening

Molecular analysis of nipple fluid for breast cancer screening.

Lack of sensitivity and specificity of image-based breast cancer screening has urged the exploration of alternate screening modalities. Nipple fluid, which contains breast epithelial cells, is produced in small amounts in the breast ducts of nonlactating women and can be collected by noninvasive vacuum aspiration. After administration of nasal oxytocin, nipple aspiration yields sufficient mater...

Hormonal determinants of nipple aspirate fluid yield among breast cancer cases and screening controls.

BACKGROUND Nipple aspiration fluid (NAF) use as a biosample is limited by the variable yield across studies. We investigated the endocrine determinants of yield in an ongoing breast cancer case-control study. METHODS One-hundred and eighteen women yielding ≥2 μL NAF and 120 non-yielders were included; serum hormones were measured; differences in median hormones were assessed using the Wilcoxo...

The role of nipple-aspirate fluid cytology in breast-cancer risk screening.

Breast Cancer and Screening

سرطان پستان یکی از شایع ترین بیماریهای بدخیم و اولین علت مرگ و میر زنان بوده و تقریبا یک سوم تمام سرطانهای زنان را تشکیل می دهد.

Proteomic analysis to identify breast cancer biomarkers in nipple aspirate fluid.

PURPOSE Proteomic analysis of breast nipple aspirate fluid (NAF) holds promise as a noninvasive method to identify markers of breast cancer. The objectives of the study were to: (a) describe the NAF proteome, (b) identify candidate markers of breast cancer in NAF by using proteomic analysis, and (c) validate the markers identified by using a quantitative, high-throughput ELISA analysis. EXPER...